ABSTRACT
<p><b>OBJECTIVE</b>To study the polysaccharide of Condonopsis pilosula.</p><p><b>METHOD</b>The polysaccharide, CPP-1, was purified by DE-52 cellulose and Sephadex G-200 gel column chromatography. Purity and molecular weight of the polysaccharide were determined by gel permeation chromatography. Methylation analysis, periodate oxidation and degradation, IR, 1H-NMR and 13C-NMR methods were adopted to elucidate the chemical structure.</p><p><b>RESULT</b>The molecular weight of CPP-1 was estimated to be 7.5 x 10(4), and the structure of CPP-1 was a beta-(2 --> 1) linked beta-D-fructosan.</p><p><b>CONCLUSION</b>CPP-1 was a neutral homosaccharide.</p>
Subject(s)
Codonopsis , Chemistry , Drugs, Chinese Herbal , Chemistry , Fructans , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To make a solid form of Angelica Sinensis essential oil by preparing its inclusion compound with beta-cyclodextrin and evaluate the inclusion rate, dissolution rate and liberating rate of this complex.</p><p><b>METHOD</b>GC-MS, X-ray diffraction and thin-layer chromatography were applied to characterize the essential oil and the inclusion compound.</p><p><b>RESULT</b>The inclusion compound was shown to form a new phase by X-ray diffraction analysis. GC-MS and TLC check-up corroborated the composition of the free oil and the inclusion oil remaining the same.</p><p><b>CONCLUSION</b>The results showed Angelica Sinensis essential oil was more stable with beta-cyclodextrin inclusion. The preparation of this inclusion compound has advantages in limited amount, long time effect, easily preserved and convenient administration as a new dosage form.</p>
Subject(s)
Angelica sinensis , Chemistry , Cyclodextrins , Dosage Forms , Drug Carriers , Drug Stability , Oils, Volatile , Plant Roots , Chemistry , Plants, Medicinal , Chemistry , Solubility , Technology, Pharmaceutical , Methods , X-Ray Diffraction , beta-CyclodextrinsABSTRACT
<p><b>AIM</b>To investigate the chemical constituents from the whole plant of the endemic plant Notoseris rhombiformis Shih.</p><p><b>METHODS</b>Column chromatography was used for separation and purification, while spectral analysis was used for structure elucidation.</p><p><b>RESULTS</b>Eight compounds were isolated from the whole plant of this Chinese endemic plant and their structures were elucidated as notoserolide A (1), notoserolide D (2), austricin (3), jacquilenin (4), 3 beta, 14-dihydroxy-11 beta, 13-dihydrocostunolide (5), p-hydroxyphenylacetic acid (6), luteolin-7-O-beta-D-glucopyranoside (7) and daucosterol (8), respectively.</p><p><b>CONCLUSION</b>All compounds were isolated from this plant for the first time. Among them, 2 is a new compound.</p>